ARTIGOS PUBLICADOS

Confira algumas das publicações com os principais resultados de pesquisas associadas com a atuação do Grupo Gerontologia Biomédica da FUnATI/UEA.

1. Publicações associadas aos Polimorfismo da enzimas Superóxido Dismutase 2

Superoxide-hydrogen peroxide imbalance interferes with colorectal cancer cells viability, proliferation and oxaliplatin response.

Azzolin VF, Cadoná FC, Machado AK, Berto MD, Barbisan F, Dornelles EB, Glanzner WG, Gonçalves PB, Bica CG, da Cruz IB. Toxicol In Vitro. 2016 Apr;32:8-15. doi: 10.1016/j.tiv.2015.12.001.

The effect of superoxide anion and hydrogen peroxide imbalance on prostate cancer: an integrative in vivo and in vitro analysis.

Berto MD, Bica CG, de Sá GP, Barbisan F, Azzolin VF, Rogalski F, Duarte MM, da Cruz IB.Med Oncol. 2015 Nov;32(11):251. doi: 10.1007/s12032-015-0700-1.

The Val16Ala-SOD2 polymorphism affects cyto-genotoxicity of pyridostigmine bromide on human peripheral blood mononuclear cells.

Azzolin VF, Barbisan F, Teixeira CF, Pillar D, Mastella MH, Duarte T, Turra BO, Ribeiro EE, Duarte MMFM, da Cruz IBM. Toxicol In Vitro. 2019 Oct;60:237-244. doi: 10.1016/j.tiv.2019.06.004.

Superoxide-hydrogen peroxide imbalance differentially modulates the keratinocytes cell line (HaCaT) oxidative metabolism via Keap1-Nrf2 redox signaling pathway.

Jobim ML, Azzolin VF, Assmann CE, Morsch VMM, da Cruz IBM, de Freitas Bauermann L. Mol Biol Rep. 2019 Dec;46(6):5785-5793. doi: 10.1007/s11033-019-05012-1.

Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β.

Barbisan F, Azzolin VF, Monteiro GC, Teixeira CF, Mastella MH, Bueno V, Duarte MMMF, Wagner G, do Prado-Lima PAS, Ribeiro EE, da Cruz IBM.Gene. 2018 May 20;655:48-55. doi: 10.1016/j.gene.2018.02.046.

Superoxide-hydrogen peroxide genetic imbalance modulates differentially the oxidative metabolism on human peripheral blood mononuclear cells exposed to seleno-L-methionine.

Schott KL, Assmann CE, Barbisan F, Azzolin VF, Bonadiman B, Duarte MMMF, Machado AK, da Cruz IBM. Chem Biol Interact. 2017 Aug 1;273:18-27. doi: 10.1016/j.cbi.2017.05.007.

The In Vitro Influence of a Genetic Superoxide-Hydrogen Peroxide Imbalance on Immunosenescence.

Barbisan F, Azzolin VF, Ribeiro EE, Duarte MMMF, da Cruz IBM.Rejuvenation Res. 2017 Aug;20(4):334-345. doi: 10.1089/rej.2016.1892. 

Cytotoxic effects of moderate static magnetic field exposure on human periphery blood mononuclear cells are influenced by Val16Ala-MnSOD gene polymorphism.

Dornelles EB, Goncalves BD, Schott KL, Barbisan F, Unfer TC, Glanzner WG, Machado AK, Cadona FC, Azzolin VF, Montano MA, Griner J, da Cruz IB. Environ Sci Pollut Res Int. 2017 Feb;24(5):5078-5088. doi: 10.1007/s11356-016-8176-x. 

The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism.

Capeleto D, Barbisan F, Azzolin V, Dornelles EB, Rogalski F, Teixeira CF, Machado AK, Cadoná FC, da Silva T, Duarte T, Duarte MM, da Cruz IB. Biogerontology. 2015 Oct;16(5):621-30. doi: 10.1007/s10522-015-9561-4.

Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism.

Barbisan F, Motta Jde R, Trott A, Azzolin V, Dornelles EB, Marcon M, Algarve TD, Duarte MM, Mostardeiro CP, Unfer TC, Schott KL, da Cruz IB.PLoS One. 2014 Oct 20;9(10):e107299. doi: 10.1371/journal.pone.0107299.

2. Publicações Com Frutos Amazônicos

Caffeinated beverages contribute to a more efficient inflammatory response: Evidence from human and earthworm immune cells.

Alves AO, Weis GCC, Unfer TC, Assmann CE, Barbisan F, Azzolin VF, Chitolina B, Duarte T, Ribeiro-Filho EE, Duarte MMMF, Boligon A, Vélez-Martin E, Palma TV, de Andrade CM, da Cruz IBM. Food Chem Toxicol. 2019 Dec;134:110809. doi: 10.1016/j.fct.2019.110809.

Interaction between low-level laser therapy and Guarana (Paullinia cupana) extract induces antioxidant, anti-inflammatory, and anti-apoptotic effects and promotes proliferation in dermal fibroblasts.

Maldaner DR, Pellenz NL, Barbisan F, Azzolin VF, Mastella MH, Teixeira CF, Duarte T, Maia-Ribeiro EA, da Cruz IBM, Duarte MMMF. J Cosmet Dermatol. 2020 Mar;19(3):629-637. doi: 10.1111/jocd.13055

The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.

Duarte T, Barbisan F, da Cunha BSN, Azzolin VF, Turra BO, Duarte MMMF, da Cruz Jung IE, Ribeiro EE, do Prado-Lima PA, da Cruz IBM. Inflammation. 2019 Jun;42(3):915-925. doi: 10.1007/s10753-018-0946-9.

Guaraná, a Highly Caffeinated Food, Presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways.

Cadoná FC, Rosa JL, Schneider T, Cubillos-Rojas M, Sánchez-Tena S, Azzolin VF, Assmann CE, Machado AK, Ribeiro EE, da Cruz IBM. Nutr Cancer. 2017 Jul;69(5):800-810. doi: 10.1080/01635581.2017.1324994.

Guaraná a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation.

Cadoná FC, Machado AK, Azzolin VF, Barbisan F, Dornelles EB, Glanzner W, Gonçalves PBD, Assmann CE, Ribeiro EE, Cruz IBMD. Anticancer Agents Med Chem. 2016;16(8):1055-1065. doi: 10.2174/1871520616666151217121138.

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs.

Hertz E, Cadoná FC, Machado AK, Azzolin V, Holmrich S, Assmann C, Ledur P, Ribeiro EE, DE Souza Filho OC, Mânica-Cattani MF, DA Cruz IB. Mol Clin Oncol. 2015 Jan;3(1):37-43.

Astrocaryum aculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages.

Cabral FL, Bernardes VM, Passos DF, de Oliveira JS, Doleski PH, Silveira KL, Horvarth MC, Bremm JM, Barbisan F, Azzolin VF, Teixeira CF, de Andrade CM, da Cruz IBM, Ribeiro EE, Leal DBR. J Ethnopharmacol. 2020 Jan 30;247:112274. doi: 10.1016/j.jep.2019.112274.

Analysis of In Vitro Cyto- and Genotoxicity of Barbatimão Extract on Human Keratinocytes and Fibroblasts.

Pellenz NL, Barbisan F, Azzolin VF, Duarte T, Bolignon A, Mastella MH, Teixeira CF, Ribeiro EE, da Cruz IBM, Duarte MMMF. Biomed Res Int. 2018 Oct 8;2018:1942451. doi: 10.1155/2018/1942451

3. Demais Publicações Associadas

Polymorphism eNOS Glu298Asp modulates the inflammatory response of human peripheral blood mononuclear cells.

Maurer P, Barbisan F, Azzolin VF, Berro LF, Montagner R, Duarte MMMF, da Cruz IBM, Manfredini V, Piccoli JDCE. Cytokine. 2020 Jan;125:154812. doi: 10.1016/j.cyto.2019.154812.

Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells.

Fernandes MS, Barbisan F, Azzolin VF, do Prado-Lima PAS, Teixeira CF, da Cruz Jung IE, Assmann CE, Riffel RT, Duarte MMMF, Aguiar-Ribeiro EM, da Cruz IBM. PLoS One. 2019 Jan 29;14(1):e0209223. doi: 10.1371/journal.pone.0209223.

The in vitro radiosensitizer potential of resveratrol on MCF-7 breast cancer cells.

da Costa Araldi IC, Bordin FPR, Cadoná FC, Barbisan F, Azzolin VF, Teixeira CF, Baumhardt T, da Cruz IBM, Duarte MMMF, Bauermann LF. Chem Biol Interact. 2018 Feb 25;282:85-92. doi: 10.1016/j.cbi.2018.01.013.

Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro.

Duarte T, Barbisan F, do Prado-Lima PAS, Azzolin VF, da Cruz Jung IE, Duarte MMMF, Teixeira CF, Mastella MH, da Cruz IBM. Cytokine. 2018 Jun;106:101-107. doi: 10.1016/j.cyto.2017.10.017.

Effects of Pyridostigmine bromide on SH-SY5Y cells: An in vitro neuroblastoma neurotoxicity model.

Azzolin VF, Barbisan F, Lenz LS, Teixeira CF, Fortuna M, Duarte T, Duarte MMFM, da Cruz IBM. Mutat Res. 2017 Nov;823:1-10. doi: 10.1016/j.mrgentox.2017.08.003. 

Regenerative potential of the cartilaginous tissue in mesenchymal stem cells: update, limitations, and challenges.

Cruz IB, Severo AL, Azzolin VF, Garcia LF, Kuhn A, Lech O. Rev Bras Ortop. 2016 Dec 6;52(1):2-10. doi: 10.1016/j.rboe.2016.11.005.

Misoprostol modulates the gene expression prostaglandin E2 and oxidative stress markers in myometrial cells.

Konopka CK, Azzolin VF, Cadoná FC, Machado AK, Dornelles EB, Barbisan F, da Cruz IB. Prostaglandins Other Lipid Mediat. 2016 Nov;126:38-45. doi: 10.1016/j.prostaglandins.2016.09.003.

Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels.

da Cruz Jung IE, Machado AK, da Cruz IB, Barbisan F, Azzolin VF, Duarte T, Duarte MM, do Prado-Lima PA, Bochi GV, Scola G, Moresco RN. Psychopharmacology (Berl). 2016 May;233(9):1715-23. doi: 10.1007/s00213-015-4079-7.