Pesquisas Realizadas


Desde a criação da FUnATI várias atividades de pesquisa passaram a ser realizadas, com destaque ao Projeto Idoso da Floresta coordenado pelo Prof. Dr.  Euler Esteves Ribeiro, fundador da FUnATI e pela Profa. Dra. Ivana Beatrice Mânica da Cruz da Universidade Federal de Santa Maria (UFSM), que atualmente é a coordenadora do Programa de Pós-Graduação em Gerontologia em nível de mestrado. Os resultados obtidos levaram à organização de um projeto complementar denominado Dieta Amazônica que tem seu foco na identificação de propriedades biológicas de frutos amazônicos que sejam benéficas na saúde e longevidade da população e sirvam como base para o desenvolvimento de produtos voltados à saúde, cosmética e cuidados paliativos. No período foram publicados mais de 73 artigos em periódicos de circulação nacional e internacional.

 Título da ProduçãoDados Editoriais
1Projeto Idoso da Floresta: indicadores de saúde dos idosos inseridos na Estratégia de Saúde da Família (ESF-SUS) de Manaus-AM, Brasil.Ribeiro et al.         Rev. Bras. Geriatr. Gerontol., 2008; 11(3):307-326
2Aspects of the health of Brazilian elderly living in a riverine municipality of Amazon rainforest.Ribeiro et al., RAGG, 2013, 3(1): 2-15.
3Functional, balance and health determinants of falls in a free living community Amazon riparian elderly.Maia-Ribeiro et al.  ArchGerontolGeriatr. 2013,  56(2):350-7.
4Association between advanced oxidation protein products and 5-year mortality risk among amazon riparian elderly population.Silva et al.,Free Radic Res. 2015 49(2):204-9.  
5Impact of functional determinants on 5.5-year mortality in Amazon riparian elderly.Antonini et al., RevPanam Salud Publica. 2016 Aug;40(1):9-15.
6Association between T102C 5-HT2A receptor gene polymorphism and 5-year mortality risk among Brazilian Amazon riparian elderly population.Silva et al. Am J Hum Biol. 2017 Sep 10;29(5).
7Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population.Chielle et al.ExpClinEndocrinol Diabetes. 2017 125(5):335-341  
8Impacto De Fatores Socioculturais, Econômicos E De Saúde Na Qualidade De Vida De Idosos Residentes Em Manaus-Am.Motta KMS. Dissertação de Mestrado. PPGERONTO-UFSM. 2015. http://repositorio.ufsm.br/handle/1/9612
9Prevalência do autorrelato da qualidade auditiva e seu impacto na sobrevivência de idosos ribeirinhos de Maués – AM.Nascimento V. Dissertação de Mestrado. PPGERONTO-UFSM. 2017.
10Transtornos afetivos em idosos brasileiros: análise das tendências de mortalidade, morbidade e custos de serviços de saúde.Souza Praia R. Dissertação de Mestrado. PPGERONTO-UFSM. 2018 http://repositorio.ufsm.br/handle/1/13061
11Superoxide imbalance triggered by Val16Ala-SOD2 polymorphism increases the risk of depression and self-reported psychological stress in free-living elderly people.Jung et al. Mol Genet Genomic Med . Fevereiro de 2020; 8 (2): e1080
  • Produção científica principal (51artigos) relacionada ao Projeto Dieta Amazônica e Fitoterápicos publicados em revistas indexadas nacionais e internacionais e relacionadas a pesquisas experimentais associadas a frutos da dieta e fitoterápicos amazônicos.
 Título da ProduçãoDados Editoriais
1Habitual intake of guaraná and metabolic morbidities: an epidemiological study of an elderly Amazonian population.Da Costa Krewer et al. Phytother Res. 2011 25(9):1367-74
2Uncariatomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial.Farias et al. Evid Based Complement Alternat Med. 2012;2012:892182.
3The protective effects of guaraná extract (Paulliniacupana) on fibroblast NIH-3T3 cells exposed to sodium nitroprusside.Bittencourt et al. Food ChemToxicol. 2013 53:119-25.
4Guaraná (PaulliniacupanaKunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study.Portella et al. Lipids Health Dis. 2013 8;12:12
5Antimicrobial activity of Amazon Astrocaryumaculeatum extracts and its association to oxidative metabolism.Jobim et al. Microbiol Res. 2014 169(4):314-23
6The in vitro genotoxic effect of Tucuma (Astrocaryumaculeatum), an Amazonian fruit rich in carotenoids.De Souza Filho et al. J MedFood. 2013 16(11):1013-21.
7Guarana effect on inflammatory and antiinflammatory cytokines is influenced by Ala16Val-SOD2 gene polymorphism.Barbisan et al. Planta Medica  2014, 80:16
8Tucumã fruit extracts (AstrocaryumaculeatumMeyer) decrease cytotoxic effects of hydrogen peroxide on human lymphocytes.Sagrillo et al. Food Chem. 2015 Apr 15;173:741-8.
9Effect of Uncariatomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells.De Oliveira et al. EvidBasedComplementAlternat Med. 2014;2014:274786.
10Effect of Paulliniacupana on MCF-7 breast cancer cell response to chemotherapeutic drugs.Hertz et al. MolClinOncol. 2015 Jan;3(1):37-43
11Guaraná, a supplement rich in caffeine and catechin, modulates cytokines: evidence from human in vitro and in vivo protocols.Krewer et al. European Food Research and Technology 2014, 239: 49-57.
12Guaraná (Paulliniacupana) improves the proliferation and oxidative metabolism of senescent adipocyte stem cells derived from human lipoaspirates.Machado et al. Food Research International 67 (2015) 426433  
13Guaraná Supplementation Modulates Tryglicerides and Some Metabolic Blood Biomarkers in Overweight Subjects.Suleiman  et al. Ann ObesDisord. 2016; 1(1): 1004.
14Genoprotective and hepatoprotective effects of Guarana (Paulliniacupana Mart. var. sorbilis) on CCl4-induced liver damage in rats.Kober et al. Drug ChemToxicol. 2016;39(1):48-52
15Hypercholesterolemia and Ecto-enzymes of Purinergic System: Effects of Paulliniacupana.Ruchel et al. Phytother Res. 2016 Jan;30(1):49-57
16Guaraná a Caffeine-Rich Food Increases Oxaliplatin Sensitivity of Colorectal HT-29 Cells by Apoptosis Pathway Modulation.Cadoná et al. Anticancer Agents Med Chem. 2016;16(8):1055-1065.
17Neuroprotective Effects of Açaí (Euterpe oleraceaMart.) against Rotenone In Vitro Exposure.Machado et al. Oxid Med Cell Longev. 2016;2016:8940850.
18Regenerative potential of the cartilaginous tissue in mesenchymal stem cells: update, limitations, and challenges.Cruz et al. RevBras Ortop. 2016 Dec 6;52(1):2-10.
19Antihyperglycemic, antioxidant activities of tucumã oil (Astrocaryumvulgare) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia.Baldissera et al.  ChemBiol Interact. 2017 May 25;270:51-58.  
20Guaraná, a Highly Caffeinated Food, presents in vitro Antitumor Activity in Colorectal and Breast Cancer Cell Lines by Inhibiting AKT/mTOR/S6K and MAPKs Pathways.Cadoná et al., NutrCancer. 2017 Jul;69(5):800-810.
21A chemical compound based on methylxanthine-polyphenols lowers nitric oxide levels and increases post-thaw human sperm viability.Werner et al. Zygote. 2017 Dec;25(6):719-730.
22Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro.Barbisan et al. Biomed Res Int. 2017;2017:4151594
23Neuroprotective Effects of Guarana (Paulliniacupana Mart.) against Vincristine in Vitro Exposure.Veloso et al. J PrevAlzheimersDis. 2018;5(1):65-70.
24Mechanisms involved in anti-aging effects of guarana (Paulliniacupana) in Caenorhabditiselegans.Arantes et al. Braz J MedBiol Res. 2018 Jul 2;51(9):e7552
25Parental and preimaginal exposure to methylmercury disrupts locomotor activity and circadian rhythm of adult Drosophila melanogaster.Algarve et al. DrugChemToxicol. 2018 Jul 22:1-11.
26Guarana (Paulliniacupana Mart.) protects against amyloid-β toxicity in Caenorhabditiselegans through heat shock protein response activation.Zamberlan et al. NutrNeurosci. 2018 Sep 9:1-11.
27Brazil nut improves the oxidative metabolism of superoxide-hydrogen peroxide chemically-imbalanced human fibroblasts in a nutrigenomic manner.Schott et al. Food ChemToxicol. 2018 Nov;121:519-526
28Analysis of In Vitro Cyto- and Genotoxicity of Barbatimão Extract on Human Keratinocytes and Fibroblasts.Pellenz et al. Biomed Res Int. 2018 Oct 8;2018:1942451.
29The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.Duarte et al. Inflammation. Inflammation. 2019 Jun;42(3):915-925.   
30Guarana improves behavior and inflammatory alterations triggered by Methylmercury exposure: an in vivo fruit fly and in vitro neural cells study.Algarve et al. 2019 Environmental Science and Pollution Research, 26(15):15069-15083
31Protective effect of guarana-loaded liposomes on hemolytic activity.Roggia et al. 2019. Colloids Surf B Biointerfaces.  Nov 11:110636.
32The Val16Ala-SOD2 polymorphism affects cyto-genotoxicity of pyridostigmine bromide on human peripheral blood mononuclear cells.Azzolin et al., 2019.Toxicol In Vitro. 2019 Oct;60:237-244. 
33Astrocaryumaculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages.Cabral et al. J Ethnopharmacol. 2020 Jan 30;247:112274. 
34Caffeinated beverages contribute to a more efficient inflammatory response: Evidence from human and earthworm immune cells.Alves et al. 2019. Food ChemToxicol.  Dec;134:110809. 
35Interaction between low-level laser therapy and Guarana (Paulliniacupana) extract induces antioxidant, anti-inflammatory, and anti-apoptotic effects and promotes proliferation in dermal fibroblasts.Maldaner et al. J CosmetDermatol. 2019 Jul 25
36Superoxide imbalance triggered by Val16Ala-SOD2 polymorphism increases the risk of depression and self-reported psychological stress in free-living elderly people.Da Cruz Jung et al. Mol Genet Genomic Med. 2019 Dec 31:e1080
37Açai (Euterpe oleracea, mart.), an Amazonian fruit has antitumor effects on prostate cancer cells.Jobim et al.  Revista de Epidemiologia e Controle de Infecção, v. 1, p. 1-18, 2019
38Healing activity of Stryphnodendronadstringens (Mart.), a Brazilian tannin-rich species: A review of the literature and a case series. Pellenz et al. Wound Medicine, v. 26, p. 100163, 2019
39Barbatimão (Stryphnodendronadstringens) na cicatrização: uma revisão. Pellenz et al. Revista Feridas, v. 2018/2019, p. 1172, 2019
40 Açaí (Euterpe oleracea Mart.) has anti-inflammatory potential through NLRP3-inflammasome modulation.Machado et al. ournal of Functional Foods, v. 56, p. 364-371, 2019.
41Lipotoxicity-associated inflammation is prevented by guarana (Paulliniacupana) in a model of hyperlipidemia.Ruchel et al. Drug ChemToxicol,Jun 14:1-9, 2019
42Guarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study.Algarve et al.Environ SciPollut Res Int. 2019 May;26(15):15069-15083
43The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone.Duarte et al. Inflammation. 2019 Jun;42(3):915-925. 
44Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells.Bottari et al. Purinergic Signal. 2019 Mar;15(1):77-84.  
45Açai (Euterpe oleracea, Mart.), an Amazonian fruit has antitumor effects on prostate cancer cells.Jobim et al. Arquivos em Biociências e Saúde , 1 (1), 61-76, 2019
46Tucumã extracts decreases PML/RARΑ gene expression in NB4/APL cell line.Arquivos em Biociências e Saúde , 1 (1), 77-98, 2019
47Evaluation in vitro of antimicrobial activity of tucumã oil (AstrocaryumVulgare).Archives in Biosciences& Health1(1), 99-112, 2019
48Protective effect of guarana-loaded liposomes on hemolytic activity.Roggia et al., Colloids Surf B Biointerfaces. 2020 Mar;187:110636
49Astrocaryumaculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages.Cabral et al.J Ethnopharmacol . 2020 30 de janeiro; 247: 112274.
50Caffeinated beverages contribute to a more efficient inflammatory response: Evidence from human and earthworm immune cells.Alves et al.Food ChemToxicol . 2019 Dec; 134: 110809. 
51Interaction between low-level laser therapy and Guarana (Paulliniacupana) extract induces antioxidant, anti-inflammatory, and anti-apoptotic effects and promotes proliferation in dermal fibroblasts.Maldaner et al. J CosmetDermatol . 2020 mar; 19 (3): 629-637. 
52Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia.  Ruchel et al. Drug Chem Toxicol. 2021 Sep;44(5):524-532.
53Amazon-derived nutraceuticals: Promises to mitigate chronic inflammatory states and neuroinflammation.Assmann et al. Neurochem Int. 2021 Sep;148:105085.
54Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules.Motta et al. J Food Biochem. 2021 Feb;45(2):e13596
55Tucumã (Astrocaryum aculeatum) Prevents Oxidative and DNA Damage to Retinal Pigment Epithelium Cells.Bonadiman et al. J Med Food. 2021 Oct;24(10):1050-1057
56Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats.  Castro et al. Life Sci. 2021 Jul 15;277:119421. doi: 10.1016/j.lfs.2021.119421
57Açaí (Euterpe oleracea Mart.) reduces the inflammatory response triggered in vitro by the antipsychotic drug olanzapine in RAW 264.7 macrophage cells.Fernandes et al. Acta Sci Pol Technol Aliment. 2021 Apr-Jun;20(2):149-163
58Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: Evidence from human and red earthworm immune cells.Teixeira et al. Food Chem Toxicol. 2021 Apr;150:1120
 
59Açaí (Euterpe oleracea Mart.) as a Potential Anti-neuroinflammatory Agent: NLRP3 Priming and Activating Signal Pathway Modulation.Cadoná et al. Mol Neurobiol. 2021 Sep;58(9):4460-4476.     
60Supplementation with açaí (Euterpe Oleracea Martius) for the treatment of chronic tinnitus: Effects on perception, anxiety levels and oxidative metabolism biomarkers.Opptiz et al (2021). CODAS (no prelo)
61Alliance Amazonas-Covid Program addressing digital health clinical and mental care actions for traditional indigenous and riverine populations adults and elderly.Cruz-Jung et al. RAGG, 12 (1):1-7, 2021